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                  DISEASE MOUSE MODELS

                  Model animals, as an important tool for human disease research, aid in the investigation of disease mechanisms and the development of therapies. Mouse models, being the most extensively used model animals, are employed in a variety of areas, such as fundamental scientific research, drug discovery, preclinical evaluation, and clinical technology development. Mice have a close relationship with humans, advanced genetic manipulation, fast reproduction, and a clear genetic background. Gene editing technology can provide suitable disease models for study based on disease-related genes. GemPharmatech has produced numerous disease models using gene editing technologies, such as spontaneous tumor models, obesity models, diabetes models, Alzheimer's disease models, Parkinson's disease models, and so on. Through phenotypic analysis, GemPharmatech has also confirmed the incidence and development of numerous model-related phenotypes, providing solid support for the research of various diseases.

                  Introducing GemPharmatech's Latest Strains: Unveiling the Future of Innovation


                  Strain ID

                  Strain Name

                  Application

                  T055223


                  B6-Tg(hSOD1 G93A,hSOD1) 圖片1.png

                  Genetic humanization, ALS disease

                  T058996

                  FAD4T-hTREM2 圖片1.png

                  Genetic humanization, Alzheimer's disease

                  T054322

                  B6-hSNCA E46K A53T

                  Genetic humanization, Parkinson's disease

                  T056757

                  B6-hCD36

                  Genetic humanization, neuroinflammation

                  T056002

                  B6-Dmd Del45

                  Duchenne muscular dystrophy, 45 exon deletion

                  T055631

                  B6-hDLL4

                  Genetic humanization, oncology

                  T056429

                  B6-hCD34

                  Genetic humanization, oncology

                  T058753

                  B6-hCEACAM5-Tg

                  Genetic humanization, oncology

                  T053316

                  B6-hIL18R1/hIL18RAP

                  Genetic humanization, oncology

                  T037007

                  B6-hCD47/hSIRPA 圖片1.png

                  Genetic humanization, oncology

                  T056010

                  BALB/c-hCD44

                  Genetic humanization, oncology

                  T054198

                  BALB/c-hGPC3

                  Genetic humanization, oncology

                  T054490

                  BALB/c-hSEMA4D

                  Genetic humanization, oncology

                  T054543

                  BALB/c-hHSA

                  Genetic humanization, oncology

                  T056432

                  BALB/c-hTROP2 圖片1.png

                  Genetic humanization, oncology

                  T056011

                  BALB/c-hCD44v6

                  Genetic humanization, oncology

                  T055714

                  BALB/c-hCS1

                  Genetic humanization, oncology

                  T056083

                  BALB/c-hLRRC15

                  Genetic humanization, oncology

                  T056430

                  BALB/c-hNECTIN-4

                  Genetic humanization, oncology

                  T058266

                  BALB/c-hTIGIT/hPVRIG

                  Genetic humanization, oncology

                  T054842

                  BALB/c-hPD1/hPDL1/hTIGIT/hCD9 圖片1.png

                  Genetic humanization, oncology

                  T058749

                  BALB/c-hPD1/hPDL1/hCD73/hCD39 圖片1.png

                  Genetic humanization, oncology

                  T009819


                  BALB/c-hHER2 圖片1.png


                  Genetic humanization, oncology

                  T009813

                  NCG-hHER2

                  Genetic humanization, oncology

                  T054081

                  NOD-Scid-hNKp30

                  Genetic humanization, oncology

                  T056195

                  B6-hIGHA1

                  Genetic humanization, autoimmune disease


                  T054583

                  BALB/c-hIL1RL1

                  Genetic humanization, autoimmune disease

                  T054645

                  BALB/c-hKLRB1

                  Genetic humanization, autoimmune disease

                  T003277

                  BALB/c-hIL17A 圖片1.png

                  Genetic humanization, autoimmune disease

                  T053555

                  BALB/c-hIL1β

                  Genetic humanization, autoimmune disease

                  T054186

                  BALB/c-hTLR8

                  Genetic humanization, autoimmune disease

                  T055268

                  BALB/c-hFcgRs/hCD47/hSIRPA 圖片1.png

                  Genetic humanization, Fc end modification for antibody drugs, ADCC effect

                  T058940

                  BALB/c-hCD3EDG/hCD22

                  Genetic humanization, CD3 bispecific antibody related

                  T057420

                  BALB/c-hCD73/hCD3EDG 

                  Genetic humanization, CD3 bispecific antibody related

                  T058817

                  BALB/c-hGPRC5D/hCD3EDG 圖片1.png

                  Genetic humanization, CD3 bispecific antibody related

                  T059045

                  BALB/c-hCD3EDG/hBCMA 圖片1.png

                  Genetic humanization, CD3 bispecific antibody related

                  T058351

                  B6-Rosa26-hAGT 圖片1.png

                  Genetic humanization, hypertension

                  T058352

                  B6-H11-hREN

                  Genetic humanization, hypertension

                  T054639

                  B6-hCD200R1

                  Genetic humanization, atherosclerosis research

                  T058217

                  B6-hAPOB-Tg

                  Genetic humanization, hypercholesteremia and atherogenesis

                  T058211

                  B6-hAPOE-DGAT2-LE1 圖片1.png

                  Genetic humanization, NASH

                  T051403

                  B6-Myh6-R404Q 圖片1.png

                  Hypertrophic cardiomyopathy

                  T027708

                  B6-Mybpc3-KO

                  hypertrophic cardiomyopathy or dilated cardiomyopathy

                  T007085

                  B6-Kras-G12D/wt; Lyz2-iCre

                  Spontaneous lung cancer

                  T053603

                  kras-G12C 圖片1.png

                  Kras-related spontaneous tumors

                  T057165

                  KPS 圖片1.png

                  Spontaneous lung cancer

                  T057162

                  KS

                  Spontaneous lung cancer


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